期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 134, 期 49, 页码 20103-20109出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja308523f
关键词
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资金
- National Institutes of Health [1DP02OD006460]
- Human Frontiers Science Program [RGY0064/2010]
- Engineering and Physical Sciences Research Council [EP/F019750/1]
- Royal Thai Government Science and Technology
- EPSRC [EP/F019750/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/F019750/1] Funding Source: researchfish
The design of novel biomaterials for regenerative medicine requires incorporation of well-defined physical and chemical properties that mimic the native extracellular matrix (ECM). Here, we report the synthesis and characterization of porous foams prepared by high internal phase emulsion (HIPE) templating using amphiphilic copolymers that act as surfactants during the HIPE process. We combine different copolymers exploiting oil water interface confined phase separation to engineer the surface topology of foam pores with nanoscopic domains of cell inert and active chemistries mimicking native matrix. We further demonstrate how proteins and hMSCs adhere in a domain specific manner.
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