4.8 Article

Highly Enantioselective Partial Hydrogenation of Simple Pyrroles: A Facile Access to Chiral 1-Pyrrolines

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 133, 期 23, 页码 8866-8869

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AMER CHEMICAL SOC
DOI: 10.1021/ja203190t

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资金

  1. National Natural Science Foundation of China [21032003, 20921092]
  2. National Basic Research Program of China [2010CB833300]
  3. Dalian Institute of Chemical Physics [K2010F1]

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A highly enantioselective Pd-catalyzed partial hydrogenation of simple 2,5-disubstituted pyrroles with a Bronsted acid as an activator has been successfully developed, providing chiral 2,5-disubstituted 1-pyrrolines with up to 92% ee.

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