期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 133, 期 31, 页码 12247-12255出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja204578e
关键词
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资金
- Robert A. Welch Foundation [C-1220, C-1222]
- Air Force Office of Scientific Research [FA9550-10-1-0469]
- National Science Foundation (IGERT) [DGE-0504425]
- NIH [U01 CA 151886-01, 5R01 CA151962-02]
Plasmon-resonant nanoparticle complexes show highly promising potential for light-triggered, remote-controlled delivery of oligo-nucleotides on demand, for research and therapeutic purposes. Here we investigate the light-triggered release of DNA from two types of nanoparticle substrates: Au nanoshells and Au nanorods. Both light-triggered and thermally induced release are distinctly observable from nanoshell-based complexes, with light-triggered release occurring at an ambient solution temperature well below the DNA melting temperature. Surprisingly, no analogous measurable release was observable from nanorod-based complexes below the DNA melting temperature. These results suggest that a nonthermal resonant, light-triggered DNA release. mechanism may play a role in plasmon
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