期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 134, 期 2, 页码 758-761出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja2077922
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资金
- BBSRC
- University of Glasgow
- Wellcome Trust [092292/Z/10/Z, 092292/B/10/Z]
- MRC [MC_U105663142] Funding Source: UKRI
- Wellcome Trust [092292/B/10/Z] Funding Source: Wellcome Trust
- Medical Research Council [MC_U105663142] Funding Source: researchfish
Depolarization of an individual mitochondrion or small clusters of mitochondria within cells has been achieved using a photoactivatable probe. The probe is targeted to the matrix of the mitochondrion by an alkyltriphenylphosphonium lipophilic cation and releases the protonophore 2,4-dinitrophenol locally in predeter mined regions in response to directed irradiation with UV light via a local photolysis system. This also provides a proof of principle for the general temporally and spatially controlled release of bioactive molecules, pharmacophores, or toxins to mitochondria with tissue, cell, or mitochondrion specificity.
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