期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 133, 期 17, 页码 6642-6649出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja110766a
关键词
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资金
- National Research Foundation of Korea (NRF)
- Korean Ministry of Education, Science, and Technology (MEST)
- BK21 Program
- National Research Foundation of Korea [R31-2011-000-10032-0, 2005-2000001, 2006-2004590, 2009-0078236, 2010-0019766] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
In this paper we report on a novel fluorescent core skeleton, 9-aryl-1,2-dihydropyrrolo[3,4-b]indolizin-3-one, which we named Seoul-Fluor, having tunable and predictable photophysical properties. Using a concise and practical one-pot synthetic procedure, a 68-member library of new fluorescent compounds was synthesized with diverse substituents. In Seoul-Fluor, the electronic characteristics of the substituents, as well as their positional changes, have a close correlation with their photophysical properties. The systematic perturbation of electronic densities on the specific positions of Seoul-Fluor, guided with the Hammett constant, allows emission wavelength tunability covering the full color range. On the basis of these observations and a computational analysis, we extracted a simple first-order correlation of photophysical properties with the theoretical calculation and accurately predicted the emission wavelength of Seoul-Fluors through the rational design. In this study, we clearly demonstrate that Seoul-Fluor can provide a powerful gateway for the generation of desired fluorescent probes without the need for a tiresome synthesis and trial-and-error process.
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