期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 133, 期 9, 页码 2795-2797出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja1100189
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资金
- Korean Government (MOEHRD) [KRF-2008-313-C00496]
- WCU [R31-2008-000-10071-0]
- Ministry of Education, Science and Technology [2010-0001953, 2010-0001954]
- National Research Council of Science & Technology (NST), Republic of Korea [C31110] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [313-2008-2-C00496, R31-2011-000-10071-0, 2009-0093116, 2009-0093117] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The individual encapsulation of living cells has a great impact on the area of cell-based sensors and devices as well as fundamental studies in cell biology. In this work, living yeast cells were individually encapsulated with functionalizable, artificial polydopamine shells, inspired by an adhesive protein in mussels. Yeast cells maintained their viability within polydopamine, and the cell cycle was controlled by the thickness of the shells. In addition, the artificial shells aided the cell in offering much stronger resistance against foreign aggression, such as lyticase. After formation of the polydopamine shells, the shells were functionalized with streptavidin by utilizing the chemical reactivity of polydopamine, and the functionalized cells were biospecifically immobilized onto the defined surfaces. Our work suggests a biomimetic approach to the encapsulation and functionalization of individual living cells with covalently bonded, artificial shells.
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