期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 133, 期 8, 页码 2583-2591出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja108846h
关键词
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资金
- BRTT Center for Targeted Nanoparticles for Imaging and Therapeutics at Case Western Reserve University
- National Foundation for Cancer Research
- National Institute of Biomedical Imaging and Bioengineering [K01EB006910]
Efficient drug delivery to tumors is of ever-increasing importance. Single-visit diagnosis and treatment sessions are the goal of future theranostics. In this work, a noncovalent PDT cancer drug-gold nanoparticle (Au NP) conjugate system performed a rapid drug release and deep penetration of the drug into tumors within hours. The drug delivery mechanism of the PDT drug through Au NPs into tumors by passive accumulation was investigated via fluorescence imaging, elemental analysis, and histological staining. The pharmacokinetics of the conjugates over a 7-day test period showed rapid drug excretion, as monitored via the fluorescence of the drug in urine. Moreover, the biodistribution of Au NPs in this study period indicated clearance of the NPs from the mice. This study suggests that noncovalent delivery via Au NPs provides an attractive approach for cancer drugs to penetrate Jeep into the center of tumors.
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