4.8 Article

Expanding the Genetic Code of an Animal

期刊

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 133, 期 36, 页码 14196-14199

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AMER CHEMICAL SOC
DOI: 10.1021/ja2054034

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资金

  1. MRC
  2. Louis Jeantet Foundation
  3. MRC [MC_U105181009, MC_UP_A024_1008] Funding Source: UKRI
  4. Medical Research Council [MC_UP_A024_1008, MC_U105181009] Funding Source: researchfish

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Genetic code expansion, for the site-specific incorporation of unnatural amino acids into proteins, is currently limited to cultured cells and unicellular organisms. Here we expand the genetic code of a multicellular animal, the nematode Caenorhabditis elegans.

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