期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 133, 期 10, 页码 3292-3295出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja111152z
关键词
-
资金
- NIH/NIGMS [GM-073949]
- NSF
- Japan Society for the Promotion of Science (JSPS)
- Spanish MICINN
- Amgen
- Bristol-Myers Squibb
A direct functionalization of a variety of quinones with several boronic acids has been developed. This scalable reaction proceeds readily at room temperature in an open flask using inexpensive reagents: catalytic silver-(I) nitrate in the presence of a persulfate co-oxidant. The scope with respect to quinones is broad, with a variety of alkyl-and arylboronic acids undergoing efficient cross-coupling. The mechanism is presumed to proceed through a nucleophilic radical addition to the quinone with in situ reoxidation of the resulting dihydroquinone. This method has been applied to complex substrates, including a steroid derivative and a farnesyl natural product.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据