期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 133, 期 15, 页码 5680-5682出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja111470n
关键词
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资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan [22000006, 20117003, 19205021]
- Grants-in-Aid for Scientific Research [20117003, 19205021, 22000006] Funding Source: KAKEN
A far-red to near-infrared (NIR) fluorescence probe, MMSiR, based on Si-rhodamine, was designed and synthesized for sensitive and selective detection of HOCl in real time. MMSiR and its oxidized product SMSiR have excellent properties, including pH-independence of fluorescence, high resistance to autoxidation and photobleaching, and good tissue penetration of far-red to NIR fluorescence emission. The value of MMSiR was confirmed by real-time imaging of phagocytosis using a fluorescence microscope. wsMMSiR, a more hydrophilic derivative of MMSiR, permitted effective in vivo imaging of HOC generation in a mouse peritonitis model. This probe is expected to be a useful tool for investigating the wide range of biological functions of HOCl.
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