期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 133, 期 5, 页码 1260-1262出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja109617y
关键词
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资金
- Alfred P. Sloan Research Fellowship
- Abbott
- Amgen
Tropylium ion mediated alpha-cyanation of amines is described. Even in the presence of KCN, tropylium ion is capable of oxidizing various amine substrates, and the resulting iminium ions undergo salt metathesis with cyanide ion to produce aminonitriles. The byproducts of this transformation are simply cycloheptatriene, a volatile hydrocarbon, and water-soluble potassium tetrafluoroborate. Thirteen total substrates are shown for the alpha-cyanation procedure, including a gram scale synthesis of 17 beta-cyanosparteine. In addition, a tropylium ion mediated oxidative aza-Cope rearrangement is demonstrated.
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