期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 133, 期 46, 页码 18530-18533出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja207345s
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资金
- Microscale Life Sciences Center, an NIH Center of Excellence in Genomic Sciences at Arizona State University [5P50 HG002360]
We describe the synthesis, properties, and application of a new fluorescent potassium chemosensor, KS2, for K+ sensing and imaging in live cells. By virtue of a strong electron-withdrawing group, 2-dicyanomethylene-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran (TCF), with a triazacryptand ligand, the new sensor can respond to K+ up to 1.6 M. This is the first highly selective intracellular sensor suitable for sensing K+ over a broad and high concentration range. Confocal fluorescence microscopy has established the utility of KS2 for live-cell K+ detection. The application of KS2 combined with other sensors will be of great benefit for investigating cellular metabolism, detecting and diagnosing diseases including cancer, and monitoring responses to therapy.
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