4.8 Article

Expedient Synthesis of N-Acyl Anthranilamides and β-Enamine Amides by the Rh(III)-Catalyzed Amidation of Aryl and Vinyl C-H Bonds with Isocyanates

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 133, 期 30, 页码 11430-11433

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AMER CHEMICAL SOC
DOI: 10.1021/ja203495c

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资金

  1. NIH [GM069559]
  2. Office of Energy Research, Office of Basic Energy Science, Chemical Sciences Division, U.S. Department of Energy [DE-AC02-05CH11231]
  3. National Sciences and Engineering Research Council of Canada (NSERC)

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A Rh(III)-catalyzed protocol for the amidation of anilide and enamide C H bonds with isocyanates has been developed. This method provides direct and efficient syntheses of N-acyl anthranilamides, enamine amides, and pyrimidin-4-one heterocycles.

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