期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 133, 期 41, 页码 16378-16381出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja207222t
关键词
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资金
- NIH [GM49216, CA112093]
- DOE [DE-AC02-05CH11231]
- NSF
Using DNA-modified electrodes, we show DNA-mediated signaling by XPD, a helicase that contains a [4Fe-4S] cluster and is critical for nucleotide excision repair and transcription. The DNA-mediated redox signal resembles that of base excision repair proteins, with a DNA-bound redox potential of similar to 80 mV versus NHE. Significantly, this signal increases with ATP hydrolysis. Moreover, the redox signal is substrate-dependent, reports on the DNA conformational changes associated with enzymatic function, and may reflect a general biological role for DNA charge transport.
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