期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 134, 期 2, 页码 765-768出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja2080949
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资金
- NIH NCRR [P41RR001614]
- National Science Foundation [DGE-0648991]
- UCSF CTSI-SOS
- Program for Breakthrough Biological Research
- American Cancer Society [IRG 97-150-10]
- Kimmel Family Foundation
- DOD BCRP [W81XWH-10-1-1023]
Cell adhesion organizes the structures of tissues and mediates their mechanical, chemical, and electrical integration with their surroundings. Here, we describe a strategy for chemically controlling cell adhesion using membrane-anchored single-stranded DNA oligonucleotides. The reagents are pure chemical species prepared from phosphoramidites synthesized in a single chemical step from commercially available starting materials. The approach enables rapid, efficient, and tunable cell adhesion, independent of proteins or glycans, by facilitating interactions with complementary labeled surfaces or other cells. We demonstrate the utility of this approach by imaging drug-induced changes in the membrane dynamics of non-adherent human cells that are chemically immobilized on a passivated glass surface.
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