4.8 Article

Aerobic Oxidative Kinetic Resolution of Secondary Alcohols with Naphthoxide-Bound Iron(salan) Complex

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 133, 期 33, 页码 12937-12939

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AMER CHEMICAL SOC
DOI: 10.1021/ja204426s

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  1. Nissan Chemical Industries, Ltd.
  2. MEXT, Japan
  3. JSPS
  4. Grants-in-Aid for Scientific Research [11J03551] Funding Source: KAKEN

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The first general method for iron-catalyzed aerobic oxidative kinetic resolution of secondary alcohols was achieved with good to high enantiomeric differentiation (k(rel) = 7-50). Although iron(salan) complex 1 does not catalyze alcohol oxidation, the naphthoxide-bound iron(salan) complex does.

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