期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 134, 期 2, 页码 893-896出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja2108307
关键词
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资金
- Eisai USA Foundation
The first total synthesis of halichondrin C has been completed, highlighted by development of the synthetic method to construct the C8-C14 polycycle. Cr-mediated coupling reactions are used seven times to form a new C C bond. The acid stability of halichondrin C is studied, demonstrating that the macrolactone stabilizes the C8-C14 polycycle, relative to the one present in the C1-C16 model.
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