期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 133, 期 34, 页码 13232-13235出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja204249p
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资金
- National Institutes of Health, National Institute of Allergy and Infectious Disease
- Rhodes Trust
- Biotechnology and Biological Sciences Research Council
- Bill and Melinda Gates Foundation
- Royal Society
- Biotechnology and Biological Sciences Research Council [BB/D005949/1, BB/E004350/1, EGA17763, BB/C510824/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/D023335/1, GR/T26542/01, EP/E000614/1, EP/G026688/1, EP/I500200/1, EP/D023343/1] Funding Source: researchfish
- BBSRC [BB/D005949/1, BB/E004350/1] Funding Source: UKRI
- EPSRC [EP/I500200/1, EP/G026688/1, EP/E000614/1] Funding Source: UKRI
Mycobacterium tuberculosis Antigen 85 enzymes are vital to the integrity of the highly impermeable cell envelope and are potential therapeutic targets. Kinetic analysis using a label-free assay revealed both mechanistic details and a substrate profile that allowed the design and construction of a selective in vitro mechanism-based inhibitor.
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