期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 133, 期 45, 页码 18110-18113出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja2086504
关键词
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资金
- European Research Council (ERC) [201749]
- Institut Universitaire de France (IUF)
- Boehringer Ingelheim Fonds
- European Research Council (ERC) [201749] Funding Source: European Research Council (ERC)
The photocleavage of a nitrobenzyl-type linker (NPPOC) at 405 nm wavelength was enabled by nucleic acid-templated energy transfer from a sensitizer (thioxanthenone) to the linker. This strategy was used to release profluorescent rhodamine, which facilitated monitoring of the reaction via fluorescence measurement in a nonoverlapping window with the sensitizer/photocleavage reaction. The rate acceleration of the templated reaction was greater than 20-fold over the background reaction. The templated reaction was used in conjunction with strand displacement to design four-component systems that responded to an analyte (DNA). Programming a specific hierarchical relationship among the four components enabled the design of a system that responded first positively and then negatively to increasing levels of an analyte.
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