期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 133, 期 6, 页码 1706-1709出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja110501v
关键词
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资金
- NSF [CHE 0948222]
- Swiss National Science Foundation
We report herein a new process, which we call contemporaneous dual catalysis, that selectively couples two highly reactive catalytic intermediates while overcoming competing trapping by stoichiometric reactive species also present in the reaction. The reaction proceeds via the convergence of a vanadium-catalyzed propargylic rearrangement and a palladium-catalyzed allylic alkylation. It generates a variety of alpha-allylated alpha,beta-unsaturated ketones, which are not readily accessible by other means. Notably, this dual catalysis is achieved using low catalyst loadings (1.0 mol % [Pd], 1.5 mol % [V]) and gives good to excellent yields (up to 98%) of the desired products.
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