期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 133, 期 42, 页码 16802-16805出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja208156z
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资金
- State University of New Jersey
- Amgen
A dual-catalysis approach, namely the combination of an achiral nucleophilic catalyst and a chiral anion-binding catalyst, was applied to the Steglich rearrangement to provide alpha,alpha-disubstituted amino acid derivatives in a highly enantioselective fashion. Replacement of the nucleophilic co-catalyst for isoquinoline resulted in a divergent reaction pathway and an unprecedented transformation of O-acylated azlactones. This strategy provided highly substituted alpha,beta-diamino acid derivatives with excellent levels of stereocontrol.
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