期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 132, 期 6, 页码 1782-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja910264z
关键词
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资金
- American Cancer Society
- Searle Scholar Award
- Camille and Henry Dreyfus New Faculty Award
Cytosine methylation oil CpG dinucleotides is all essential epigenetic modification ill eukaryotes. How DNA methylation modulates nucleosome structure and dynamics has been a long-standing question. We implemented a single-molecule method to monitor the effects of DNA methylation on the structure and dynamics of mononucleosomes. Our studies show that DNA methylation induces a more compact and rigid nucleosome structure, providing a physical basis for how DNA methylation might contribute to regulating chromatin structure.
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