期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 132, 期 4, 页码 1255-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja908906n
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资金
- JSPS [20037010]
- MEXT
- Kato Memorial Bioscience Foundation
- Grants-in-Aid for Scientific Research [20685008, 20037010] Funding Source: KAKEN
A highly enantioselective catalytic asymmetric access to 3-aminooxindoles with a tetrasubstituted carbon stereocenter is described. 1-2 mol % of homobimetallic (R)-Ni-2-Schiff base 1 catalyzed the asymmetric amination of 3-substituted oxindoles with azodicarboxylates to give (R)-products in 99-89% yield and 99-87% ee. Reversal of enantiofacial selectivity was observed between bimetallic and monometallic Schiff base complexes, and monometallic (R)-Ni-Schiff base 2c gave (S)-products in 98-80% ee. Transformation of the products into an optically active oxindole with a spiro-beta-lactam unit and a known key intermediate for AG-041R synthesis is also described.
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