期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 132, 期 44, 页码 15534-15536出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja1079755
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资金
- National Science Foundation [CHE 0846427]
Herein we report palladium-catalyzed asymmetric benzylic alkylation with 3-aryl oxindoles as prochiral nucleophiles. Proceeding analogously to asymmetric allylic alkylation, asymmetric benzylation occurs in high yield and enantioselectivity for a variety of unprotected 3-aryl oxindoles and benzylic methyl carbonates using chiral bisphosphine ligands. This methodology represents a novel asymmetric carbon-carbon bond formation between a benzyl group and a prochiral nucleophile to generate a quaternary center.
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