期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 132, 期 30, 页码 10272-10274出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja104917t
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资金
- Korea Research Foundation [KRF-2008-C00024]
- MIRC [NRF-2010-0001957]
- National Research Foundation of Korea [2009-0093123, 2008-0093870] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
An unprecedented protocol for cyanation at arene C-H bonds has been developed by employing N,N-dimethylformamide and ammonia as a combined source for the cyano CN unit. Isotopic incorporation experiments revealed that the carbon and nitrogen of the CN originate from the N,N-dimethyl moiety of DMF and ammonia, respectively. The present cyanation reaction shows an excellent degree of regioselectivity, producing only monosubstituted nitriles at the less hindered C-H position, and it allows for the preparation of doubly labeled nitrile compounds for the first time.
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