期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 132, 期 28, 页码 9600-9601出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja103240g
关键词
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资金
- NSF [DMR 0520567/CMMI 0709131]
- NSERC of Canada
We introduce a new sensing modality based on the actuation of discrete gold nanoparticle dimers. Binding of the target DNA leads to a geometrical extension of the dimer, thereby yielding a spectral blue shift in the hybridized plasmon mode as detected by single nanostructure scattering spectroscopy. The magnitude and opposite direction of this shift enabled us to spectroscopically distinguish the target from nonspecific binding and to detect the target in complex media like serum.
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