期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 132, 期 23, 页码 7838-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja101677r
关键词
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资金
- NIH [5-U54-CA119349-05, 5R01CA126642-02, U01-HL080731, T32-CA79443]
- MIT DCIF [CHE-980806, DBI-9729592]
- Samsung
We present a bioorthogonal and modular conjugation method for efficient coupling of organic dyes and biomolecules to quantum dots (QDs) using a norbornene-tetrazine cycloaddition. The use of noncoordinating functional groups combined with the rapid rate of the cycloaddition leads to highly efficient conjugation. We have applied this method to the in situ targeting of norbornene-coated QDs to live cancer cells labeled with tetrazine-modified proteins.
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