期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 132, 期 20, 页码 6910-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja103080d
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资金
- NSERC
- University of Ottawa
- Amgen
- Eli Lilly
- Astra Zeneca
The rhodium(III)-catalyzed hydroarylation of internal alkynes is described. Good yields are obtained for a variety of alkynes, and excellent regioselectivity is observed for unsymmetrically substituted alkynes. The reaction also gives good yields for a range of arenes. Preliminary mechanistic investigations suggest that this reaction proceeds through arene metalation with the cationic rhodium catalyst, which enables challenging intermolecular reactivity.
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