期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 132, 期 51, 页码 18012-18013出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja108127r
关键词
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资金
- Japan Science and Technology Agency (JST)
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [19054011, 22760541]
- Grants-in-Aid for Scientific Research [19054011, 22760541] Funding Source: KAKEN
A label-free immunosensor based on an aptamer-modified graphene field-effect transistor (G-FET) is demonstrated. Immunoglobulin E (IgE) aptamers with an approximate height of 3 nm were successfully immobilized on a graphene surface, as confirmed by atomic force microscopy. The aptamer-modified G-FET showed selective electrical detection of IgE protein. From the dependence of the drain current variation on the IgE concentration, the dissociation constant was estimated to be 47 nM, indicating good affinity and the potential for G-FETs to be used in biological sensors.
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