期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 132, 期 3, 页码 932-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja907075s
关键词
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资金
- National Natural Science Foundation of China [20675078, 20890020]
- 973 Projects [2009CB930100, 2010CB933600]
Fluorescent silver nanoclusters were successfully synthesized using hybridized DNA duplexes as capping scaffolds. The formation of these emitters was highly sequence-dependent and could specifically identify a single nucleotide mutation, the sickle cell anemia gene mutation. Furthermore, the identification of single-nucleotide differences using this strategy was extended to more general types of single-nucleotide mismatches.
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