期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 132, 期 44, 页码 15474-15476出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja1048972
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资金
- National University of Singapore [143-000-428-112]
A novel amino-thiocarbamate-catalyzed bromolactonization of unsaturated carboxylic acids has been developed. The scope of the reaction is evidenced by 22 examples of gamma-lactones with up to 99% yield and 93% ee. The protocol was applied in the enantioselective synthesis of the key intermediates of VLA-4 antagonists.
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