4.8 Article

A New Route to Carbohydrate Secondary and Tertiary Structure Using Raman Spectroscopy and Raman Optical Activity

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 132, 期 31, 页码 10654-10655

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AMER CHEMICAL SOC
DOI: 10.1021/ja104077n

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  1. Engineering and Physical Sciences Research Council [GR/S75727/01] Funding Source: researchfish

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The structural characterization of carbohydrate polymers is important for understanding their functions and behavior. However, mainstream structural biology tools are not applicable to many carbohydrate polymers, particularly at physiological concentrations. We report Raman and Raman optical activity spectra of hyaluronan polymer, the hyaluronan tetramer building block, and the two monosaccharide components glucuronic acid and N-acetylglucosamine and identify marker bands corresponding to primary and secondary structure in glycosaminoglycans. Furthermore, we show that the hyaluronan polymer does not adopt tertiary structure under near-physiological conditions, confirming a proposed model of hyaluronan structural organization.

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