期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 132, 期 12, 页码 4381-4387出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja910653k
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资金
- UPMC
- CNRS
- IUF
- ANR [BLAN0309]
- Region Ile-de-France
A newly designed radical cascade involving N-acyl cyanamides is reported. It builds on aromatic homolytic substitutions as intermediate events and leads to complex heteroaromatic structures via an unprecedented radical migration of a substituent on aryl groups of quinazolinones (hydrogen or alkyl). Mechanistic considerations are detailed, which allowed us to devise fine control over the domino processes. The latter could be predictably stopped at several stages, depending on the reaction conditions. Finally, a surgical introduction of a trifluoromethyl substituent on a quinazolinone was achieved via the reported migration.
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