期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 132, 期 10, 页码 3298-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja100502f
关键词
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资金
- ACS PRF [47272AC]
- NSF [CHE 0957462]
- NIH [R01-GM082961]
A reagent controlled organocatalytic enantioselective chlorolactonization reaction has been developed. Several 4-aryl pentenoic acids were cyclized in the presence of 0.1 equiv of (DHQD)(2)PHAL, employing various N-chlorinated hydantoins as the terminal chlorenium source. Ten examples are presented with selectivities ranging from 43 to 90% ee. This work represents the first example of an enantioselective reagent-controlled chlorolactonization that approaches synthetically useful enantioselectivities.
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