期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 132, 期 46, 页码 16417-16422出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja106506k
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资金
- Iowa State University [DE-AC02-07CH11358]
- Chemical Sciences, Geosciences, and Biosciences Division
- Basic Energy Sciences
- Office of Science
- U.S. Department of Energy
- Iowa Center for Advanced Neurotoxicology
Gold nanorods are excellent orientation probes due to their anisotropic optical properties. Their dynamic rotational motion in the 3D space can be disclosed with Nomarski-type differential interference contrast (DIC) microscopy. We demonstrate that by using the combination of gold nanorod probes and DIC microscopy, we are able to resolve rotational motions of nano-cargos transported by motor proteins at video rate not only on engineered surfaces but also on cytoskeleton tracks in live cells.
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