期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 132, 期 26, 页码 8836-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja101690u
关键词
-
资金
- National Institute of General Medical Sciences [GM-49093]
The straightforward protonation of lactams by treatment with acid and the full structural characterization of three resulting N-protonated lactams are disclosed. This work provides experimental evidence that N-protonation of amide bonds results in a dramatic increase in nonplanarity about the C-N amide bond. The resulting compounds are discussed in structural, spectroscopic, and reactivity terms. The data suggest that distortion of these amide bonds by similar to 50 degrees is sufficient for their effective N-activation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据