4.8 Article

Pd(II)-Catalyzed Enantioselective C-H Olefination of Diphenylacetic Acids

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 132, 期 2, 页码 460-+

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AMER CHEMICAL SOC
DOI: 10.1021/ja909571z

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  1. Scripps Research Institute
  2. National Institutes of Health (NIGMS) [1 R01 GM084019-01A1]
  3. Amgen
  4. Lilly

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Pd(II)-catalyzed enantioselective C-H olefination of diphenylacetic acid Substrates has been achieved through the use of monoprotected chiral amino acid ligands. The absolute configuration of the resulting olefinated products is consistent with that of a proposed C-H insertion intermediate.

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