期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 132, 期 20, 页码 6906-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja102414t
关键词
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资金
- Pacific Northwest National Laboratory (PNNL)
- Washington Research Foundation
- University of Washington Institute of Translational Health Sciences
- NIH [R01GM080987, R01CA134487]
- U.S. Dept. of Energy [KC020105-FWP12152, DE-AC06-RLO1830]
We report that antibodies can be spontaneously loaded in functionalized mesoporous silica (FMS) with superhigh density (0.4-0.8 mg of antibody/mg of FMS) due to their comprehensive noncovalent interaction. The superhigh loading density and noncovalent interaction between FMS and antibodies allow long-lasting local release of the immunoregulatory molecules from FMS under physiological conditions. Preliminary data indicate that FMS-anti-CTLA4 antibody injected directly into a mouse melanoma induces much greater and extended inhibition of tumor growth than the antibody given systemically. Our findings open up a novel approach for local delivery of therapeutically active proteins to tumors and, potentially, other diseases.
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