期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 132, 期 33, 页码 11416-11417出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja1052335
关键词
-
资金
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- University of Toronto
- Merck-Frosst Canada for an industrial research chair
A Pd(0)-catalyzed C-N bond-forming reaction leading to the synthesis of brominated indoles is described. The use of the phosphine ligand PtBu3 is necessary for reactivity. It is proposed that the bulky ligand serves to prevent inhibition of the catalyst by facilitating reversible oxidative addition into the product C-Br bond. Intramolecular coupling of a vinyl bromide in the presence of an aryl iodide can take place, demonstrating unprecedented levels of selectivity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据