期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 132, 期 40, 页码 14137-14151出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja105044s
关键词
-
资金
- The Scripps Research Institute (TSRI)
- NIH (NIGMS) [1 R01 GM084019-01A1]
- NSF [NSF CHE-1011898]
- Amgen
- Eli Lilly
- A. P. Sloan Foundation
- China Scholarship Council
- DOD
- Skaggs-Oxford Scholarship
Initial rate studies have revealed dramatic acceleration in aerobic Pd(II)-catalyzed C-H olefination reactions of phenylacetic acids when mono-N-protected amino acids are used as ligands. In light of these findings, systematic ligand tuning was undertaken, which has resulted in drastic improvements in substrate scope, reaction rate, and catalyst turnover. We present evidence from intermolecular competition studies and kinetic isotope effect experiments that implies that the observed rate increases are a result of acceleration in the C-H cleavage step. Furthermore, these studies suggest that the origin of this phenomenon is a change in the mechanism of C-H cleavage from electrophilic palladation to proton abstraction.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据