期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 132, 期 32, 页码 11179-11182出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja103551x
关键词
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资金
- NSF [0541775]
- NIH [GM42056]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0840401, 0541775] Funding Source: National Science Foundation
Structurally complex and physiologically active natural products often include bicyclic and polycyclic ring systems having defined relative and absolute configuration. Approaches that allow the construction of more than one carbocyclic ring at a time have proven valuable, in particular those that allow at the same time the control of an array of new stereogenic centers. One of the most general and most widely used protocols has been the intramolecular Diels-Alder [4 + 2] cycloaddition, in which a single stereogenic center between the diene and the dienophile can control the relative and absolute configuration of the product. We report a two-step [1 + 4 + 1] procedure for bicyclic and polycyclic construction, based on the cyclization of an omega-dienyl ketone. This is complementary to, and will likely be as useful as, the intramolecular Diels-Alder cycloaddition.
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