期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 132, 期 28, 页码 9546-9548出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja102733a
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资金
- Nanyang Technological University
- Singapore Ministry of Education [T207B1220RS]
- Novartis Institute for Tropical Diseases
The scope of the catalyst-free water-based Mukaiyama aldol reaction was explored through its application to the site-selective functionalization of N-terminal aldehydes of peptides and proteins. Various functional groups were introduced under mild and environmentally friendly conditions, with the first demonstration of aldol C-C bond formation in protein labeling studies. The efficiency and speed achieved in protein labeling can be of special interest in chemical biology studies.
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