期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 132, 期 18, 页码 6276-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja9102259
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资金
- National Science Foundation [CHE-0705290]
- GlaxoSmithKline
- 3M
- Amgen
- Eli Lilly
The synthesis of (dppf)Pd(C6H4-p-F)[N(Ar-1)(CH2)(3)CH=CH2] complexes (3), which are thought to be intermediates in Pd-catalyzed alkene carboamination reactions, is described. These complexes undergo syn-migratory insertion of the alkene into the Pd-N bond to yield observable (dppf)palladium(aryl)(pyrrolidin-2-yl-methyl) complexes 6. Reductive elimination from 6 provides 2-benzylpyrrolidine derivatives 4. The rates of conversion of 3 to 6 (k(1)) and 6 to 4 (k(2)) were measured and are within 1 order of magnitude of each other. The syn-migratory insertion stereochemistry was confirmed through a deuterium labeling experiment. These are the first examples of syn-migratory insertions of unactivated alkenes into Pd-N bonds of well-defined complexes.
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