期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 132, 期 50, 页码 17928-17932出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja108568g
关键词
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资金
- National Institutes of Health (Carolina Center of Cancer Nanotechnology) [1R01EB009565-02, U54CA119373, 1DP10D006432-01]
- University of North Carolina at Chapel Hill
- Liquidia Technologies
Responsive polymeric biomaterials can be triggered to degrade using localized environments found in vivo. A limited number of biomaterials provide precise control over the rate of degradation and the release rate of entrapped cargo and yield a material that is intrinsically nontoxic. In this work, we designed nontoxic acid-sensitive biomaterials based on silyl ether chemistry. A host of silyl ether cross-linkers were synthesized and molded into relevant medical devices, including Trojan horse particles, sutures, and stents. The resulting devices were engineered to degrade under acidic conditions known to exist in tumor tissue, inflammatory tissue, and diseased cells. The implementation of silyl ether chemistry gave precise control over the rate of degradation and afforded devices that could degrade over the course of hours, days, weeks, or months, depending upon the steric bulk around the silicon atom. These novel materials could be useful for numerous biomedical applications, including drug delivery, tissue repair, and general surgery.
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