4.8 Article

Pd(II)-Catalyzed Hydroxyl-Directed C-H Activation/C-O Cyclization: Expedient Construction of Dihydrobenzofurans

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 132, 期 35, 页码 12203-12205

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AMER CHEMICAL SOC
DOI: 10.1021/ja105366u

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  1. U.S. National Science Foundation (NSF) [CHE-1011898]
  2. Scripps Research Institute
  3. Pfizer
  4. China Scholarship Council
  5. Division Of Chemistry
  6. Direct For Mathematical & Physical Scien [1011898] Funding Source: National Science Foundation

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A Pd(II)-catalyzed C-H activation/C-O cyclization reaction directed by a proximate hydroxyl group has been developed. This reaction provides a new method for constructing dihydrobenzofurans, including spirocyclic analogues, a process that is potentially applicable to natural product synthesis.

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