期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 132, 期 10, 页码 3238-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja909165u
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资金
- Research Councils UK
- Cancer Research UK
- Cancer Research UK [6947] Funding Source: researchfish
The identification, synthesis, and evaluation of a series of naphthoquinone derivatives as selective inhibitors of human arylamine N-acetyltransferase 1 and mouse arylamine N-acetyltransferase 2 are described. The compounds undergo a distinctive color change (red -> blue) upon binding to these human and mouse NAT isoenzymes driven by a proton transfer event. No color change is observed in the presence of functionally distinct but highly similar isoenzymes which are >70% identical. These molecules may be used as sensors to detect the presence of human NAT1 in cell lysates.
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