期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 132, 期 18, 页码 6309-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja100399m
关键词
-
资金
- NHLBI NIH HHS [R01HL053315, R01 HL053315, R01 HL053315-13] Funding Source: Medline
- NIDDK NIH HHS [R33DK070291, R33 DK070291] Funding Source: Medline
- NIEHS NIH HHS [R01 ES013925, R01ES013925] Funding Source: Medline
4-Hydroxyacids are ubiquitous in human physiology. They are derived from the drugs of abuse gamma-hydroxybutyrate (GHB), gamma-hydroxypentanoate(GHP), in addition to the omnipresent lipid peroxidation product 4-hydroxy-2-(E)-nonenal (4-HNE). Previously we reported that 4-hydroxyacids are catabolized through two parallel pathways. In this report we detail two isotopic tools that have allowed the dissection of this catabolic process and illustrate how these tools can be used to quantify the relative flux down each pathway. We found that 4-hydroxynonanoate (4-hydroxyacid derived from 4-HNE) is primarly catabolized through a pathway that phosphorylates the C-4 hydroxyl and isomerizes it to a C-3 hydroxy compound, which is catabolized through B-oxidation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据