期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 132, 期 6, 页码 1758-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja909690a
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资金
- National Institute on Aging [SC1AG034197]
- Division Of Computer and Network Systems
- Direct For Computer & Info Scie & Enginr [0855217] Funding Source: National Science Foundation
We report DFT calculations indicating that P-sheet formation involving the capped amino acid sequence VQIVYK is due (at least in part) to cooperative H-bonding between the glutamine side chains. The sequence VQIVYK has been reported to be essential for the aggregation of the tau protein into the amyloids associated with Alzheimer's disease and has been crystallized. Sheets containing only capped Q's form cooperative H-bonds between the side chains that enhance stabilization while keeping the backbones of the individual strands close to the quasi-planarity expected for a beta-sheet. Sheets containing only capped A's cannot form H-bonds between the side chains, do not interact cooperatively, and Form helical structures that deviate considerably From the quasi-planarity expected for beta-sheets. Comparisons between the sheets made from capped VQIVYK's, Q's, and A's illustrate the importance of the cooperative H-bonds between the Q's to the stability of URI amyloids.
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