期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 132, 期 49, 页码 17396-17398出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja1088925
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资金
- National Science Foundation [CHE-0844946]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0844946] Funding Source: National Science Foundation
The presence of HMPA is critical for the selective coupling of alkyl halides and ketones by Sml(2). Although previous rate studies have shown that HMPA dramatically accelerates the reduction of alkyl halides over ketones, the basis of this rate acceleration is unknown. In this communication, we report experimental and computational evidence that demonstrate that the selectivity observed in the samarium Barbier reaction is in part a result of activation of the alkyl halide bond by HMPA.
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