期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 132, 期 20, 页码 6908-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja102571b
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资金
- NSERC
- University of Ottawa
- Eli Lilly
- Amgen
- AstraZeneca
- Sloan Foundation
- OGS
An external-oxidant-free process to access the isoquinolone motif via cross-coupling/cyclization of benzhydroxamic acid with alkynes is described. The reaction features a regioselective cleavage of a C-H bond on the benzhydroxamic acid coupling partner as well as a regioselective alkyne insertion. Mechanistic studies point out the important involvement of a N-O bond as a tool for C-N bond formation and catalyst turnover.
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